{"id":7629,"date":"2022-06-08T18:04:26","date_gmt":"2022-06-08T18:04:26","guid":{"rendered":"https:\/\/www.simbhq.org\/np\/?page_id=7629"},"modified":"2022-11-17T19:19:14","modified_gmt":"2022-11-17T19:19:14","slug":"genome-mining-workshop","status":"publish","type":"page","link":"https:\/\/www.simbhq.org\/np\/genome-mining-workshop\/","title":{"rendered":"Genome Mining for Natural Product Biosynthesis"},"content":{"rendered":"

Genome Mining for Natural Product Biosynthesis<\/span><\/h2>\n<\/div>
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Genome sequencing has been democratized and transformed into a powerful tool that drives natural products discovery. By examining the genome of a specialized metabolite producer, we can get an idea of its capacity to produce new natural products. In this interactive two-hour workshop, participants will get hands-on experience in applying comprehensive bioinformatics analyses to investigate the biosynthetic potential of a newly-sequenced actinobacterial genome. Participants will learn to calculate the whole-genome phylogeny of the sequenced strain to give an idea of its taxonomic novelty. They will learn to generate and interpret the results of antiSMASH, a tool that identifies biosynthetic gene clusters (BGCs) from the genome sequence. Then, they will also learn to leverage several state-of-the-art tools to map these BGCs onto the global atlas of homologous BGC families, which may give a clue about the novelty of the encoded pathways. Finally, participants will be guided to apply the ARTS tool to predict self-resistance genes in each BGC, which serves as a first hint to the compound\u2019s antimicrobial properties and mechanism-of-action.<\/span><\/p>\n<\/div>

Who Should Attend?<\/span><\/h3>\n

Students and postdocs attending the NP 2023 meeting.<\/span><\/p>\n<\/div>

What to bring?<\/span><\/h3>\n

Attendees are invited to bring their own laptops, pen and notepaper.
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Tuesday, January 10, 2023<\/h2>\n

1:30 – 3:30pm<\/h3>\n<\/div>
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Location<\/h3>\n

Manchester Grand Hyatt San Diego
\nSan Diego, CA<\/p>\n<\/div>

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Registration<\/h3>\n

The workshop is full. Registration for this workshop is closed.<\/p>\n<\/div>

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Presenters<\/h3>\n

Satria Kautsar and Edward Kalkreuter, Scripps<\/p>\n<\/div>

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