Alternative fermentation systems
Stainless stirred tank bioreactors have been the gold standard for industrial fermentation processes and can be considered a very matured technology with many decades of troubleshooting and optimization. However, not all bioprocesses can be successfully implemented and scaled using this traditional technology, and there is an increasing move to reduce cross-contamination risks and culture volumes while increasing product titres. Thus, this session will cover all aspects of non-conventional approaches to fermentation, their scale-up challenges and solutions, new developments, and control strategies. Topics of presentation include systems modelling, bioreactor designing, process automation, single-use, plug flow, hollow fiber, solid-state, micro-fermentors, and others. Novel approaches in scaling-up alternative fermentation systems, scaling-up by number versus scaling up by volume, and downstream specificities concerning these alternative systems is of particular focus.